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KMID : 1143820060020010045
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Anxiety and Mood
2006 Volume.2 No. 1 p.45 ~ p.49
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Association between Panic Disorder and Dopamine D2 Receptor Taql A Poymorphism
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Lim Se-Won
Kim Bum-Jo
Oh Kang-Seob
Lee Min-Soo
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Abstract
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Puropse : Disturbances of dopaminergic system might be related to the possible mechanism of panic disorder. This study was aimed to examine the association of DRD2 Taq 1 polymorphism and panic disorder.
Methods : One hundred and fourteen patients with panic disorder (62 male (54.4%), mean age years) and 200 comparison subjects (114 male (57.0%), mean age years)were tested for DRD2 TaqI A polymorphism. We excluded panic patients with comorbid alcohol related disorders, bipolar disorders, and any kinds of psychotic disorders because there have been some reports about association of these disease and DRD2 TaqI A polymorphism.
Results : There was significant difference in the frequency of the genotype in DRD2 polymorphism between patients and controls (=6.09, df=2, p=0.048). The A1+ allele (A1A1 and A1A2) frequency analysis also showed significant association (=4.08, df=1, p=0.043). In addition, we observed a more strong and specific association between panic disorder and the A1+ allele of the DRD2 TaqI polymorphism for men (=4.71, df=1, p=0.03), but not for women (=0.45, df=1, p=0.50).
Conclusion : These results in our Korean sample suggest that the DRD2 TaqI A polymorphism may be associated with panic disorder. Furthermore, we found sex-specific association of DRD2 A1 allele with panic disorder.
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KEYWORD
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Panic disorder, Dopamine, Polymorphism, Gender
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